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Doctorpedia Reviews


November 6, 2019



Prucalopride is used to treat chronic idiopathic constipation (CIC; difficult or infrequent passage of stools that lasts for 3 months or longer and is not caused by a disease or a medication). Prucalopride is in a class of medications called serotonin receptor agonists. It works by increasing the movement of waste through the bowel.




Prucalopride comes as a tablet to take by mouth. It is usually taken with or without food once a day. Take prucalopride at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take prucalopride exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.


Ask your pharmacist or doctor for a copy of the manufacturer’s information for the patient.


Before taking prucalopride,


  • tell your doctor and pharmacist if you are allergic to prucalopride, any other medications, or any of the ingredients in prucalopride tablets. Ask your pharmacist for a list of the ingredients.
  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
  • tell your doctor if you have a hole or blockage in your stomach or intestines or an inflammatory condition of the intestinal tract such as Crohn’s disease (a condition in which the body attacks the lining of the digestive tract, causing pain, diarrhea, weight loss, and fever), ulcerative colitis (condition that causes swelling and sores in the lining of the large intestine), or toxic megacolon or megarectum (life-threatening widening of the intestine or rectum). Your doctor will probably tell you not to take prucalopride.
  • tell your doctor if you have or have ever had depression, suicidal thoughts or actions (thinking about harming or killing oneself or planning or trying to do so), or other mood problems, or kidney disease.
  • tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking prucalopride, call your doctor.
  • you should know that your mental health may change in unexpected ways during treatment with prucalopride. You, your family, or your caregiver should call your doctor right away if you experience any of the following new symptoms or a worsening of these symptoms: depression; thinking about harming or killing yourself, or planning or trying to do so; or changes in mood or behavior. Be sure that your family or caregiver know these symptoms may be serious so they can call the doctor if you are unable to seek treatment on your own.


Side Effects


Prucalopride may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:


  • headache
  • stomach pain
  • nausea
  • diarrhea
  • dizziness


Some side effects can be serious. If you experience any of these symptoms, stop taking prucalopride and call your doctor immediately or get emergency medical treatment:


  • difficulty breathing or shortness of breath
  • rash
  • itching
  • hives
  • swelling of face, lips, tongue, or throat


Prucalopride may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.


If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting program online ( or by phone (1-800-332-1088).




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